Irritation from the application of alpha-hydroxy acids or other acid formulations may result
in the removal of several layers of the skin. Depending on the strength of the product and the
frequency of application, the removal
of epidermal layers can compromise the barrier function of the skin. NOVA instrumentation
may be used to track the effect, allowing researchers to monitor the barrier functionality.
Because the barrier function is a naturally
resistive element of the skin, when it is compromised, impedance readings will increase.